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As previously described, common molecular contributors to neurodegeneration such as oxidative stress, mitochondrial dysfunction, and glial activation also play central roles in MS pathogenesis

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Factors influencing APAP-related hepatotoxicity The most essential determining factor in both the development and severity of APAP hepatotoxicity is the drugs ingested dose, but some argue that the length of time from APAP ingestion to N -acetylcysteine (NAC) therapy (time to NAC) is equally if not more important